Table of properties of different domains that bind to phospho-peptides.

(The binding is at phospho-serine / phospho-threonine / phospho-tyrosine denoted by X)

(Look out for the above color code)

No	Binding Domain	Domain Str. Eg.	Examples: Structure - Protein - Binding site - View			Consensus binding site^* – Prosite Entry	Annotation - References
1	FHA	1DMZ, 1FHQ, 1G3G, 1J4O, 1K3J, 1QU5.	1G6G	No name.	SLEVXEADATFAK.	EDIXYLD.	In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. [1], [2], [3], [4].
			1FHR	DNA repair protein.	EDIXYLD.
			1GXC	Synthetic.	RHFDXYLIRR.
			1J4K	DNA repair protein.	EDIXYLD.
			1J4L	DNA repair protein.	EVELXQELP.
			1J4P	DNA repair protein.	KKMTFQXPTDPLE.
			1J4Q	DNA repair protein.	SLEVXEADATFVQ.
			1K2M	DNA repair protein.	EDIXYLD.
			1K2N	DNA repair protein.	EVELXQELP.
			1K3N	DNA repair protein.	KKMTFQXPTDPLE.
			1K3Q	DNA repair protein.	SLEVXEADATFVQ.
2	14_3_3	1A38, 1O9C, 1O9E.	1A37	Ps-Raf259 Peptide.	KSQRQRSTXTPNVHM.	QSYXV.	14-3-3 homologues mediate signal transduction by binding to phosphoserine containing proteins. [5], [6].
			1QJA	Phosphopeptide.	RLYHXLPA.
			1QJB	Phosphopeptide.	ARSHXYPA/RSHXYPA
			1O9D	Plasma Membrane H+ Atpase.	QSYXV.
			1O9F	Plasma Membrane H+ Atpase.	QSYXV.
3	WW	1EOM, 1I6C, 1PIN, 1J6Y.	1F8A	Y(Sep)Pt(Sep)S Peptide.	YXPTXPS.	YXPTXPS.	Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides. [7], [8], [9].
			1I8G	M-Phase Inducer Phosphatase 3.	EQPLXPVTDL.
			1I8H	Microtubule-Associated Protein Tau.	KVSVVRXPPKSPS.
4	Vhs	1ELK, 1DVP, 1JWF, 1MHQ.	1LF8	Ci Man-6-P Receptor.	FHDDXDEDLLHI.	FHDDXDEDLLHI.	Domain present in VPS-27, Hrs and STAM. [10], [11].
5	HprK	1JB1, 1KKL.	1KKM	Phosphocarrier Protein Hpr.	~TVNLKXIMGVM~	~TVNLKXIMGVM~	Serine kinase of the HPr protein regulates carbohydrate metabolism [Signal transduction mechanisms]. [12], [13].
6	DSP	1VHR.	1J4X	DDE(Ahp)(Tpo)G (Ptr)VATR.	DDEXXGXVATR.	DDEXXGXVATR.	Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Characterized as VHR- or Cdc25-like. [14].
7	KIX	1JJS.	1KDX	Creb.	~SRRPXYRKIL~	~SRRPXYRKIL~	CBP and P300 bind to the CREB via a domain known as KIX. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun. [15].
8	MH2	1DD1.	1KHX	Smad2 Protein.	~VRCSXMX.	~VRCSXMX.	MH2 domain. This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins. The MH2 domain mediates interaction with a wide variety of proteins. [16], [17].
9	WD40	1ERJ.	1NEX	GLL(Tpo)PPQSG.	GLLXPPQSG.	GLLXPPQSG.	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. [18].
10	PKI		1STC	Capk. – SEP & TPO.	~AAKKGXEQESV~ ~EEIRVXINEKC~ ~KGRTWXLCGTP~	~EEIRVXINEKC~ ~AAKKGXEQESV~ ~KGRTWXLCGTP~ cAMP and cGMP	cAMP-dependent protein kinase inhibitor (PKI). Members of this family are extremely potent competitive inhibitors of camp-dependent protein kinase (Capk) activity. These proteins interact with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. [23], [19], [20], [21], [22], [24].
			1FMO	Capk. – SEP & TPO.	~EEIRVXINEKC~ ~KGRTWXLCGTP~
			1YDR	Capk. – SEP & TPO.	~EEIRVXINEKC~ ~KGRTWXLCGTP~
			1YDS	Capk. – SEP & TPO.	~EEIRVXINEKC~ ~KGRTWXLCGTP~
			1YDT	Capk. – SEP & TPO.	~EEIRVXINEKC~ ~KGRTWXLCGTP~
			1JBP	Capk. – SEP & TPO.	~AAKKGXEQESV~ ~EEIRVXINEKC~ ~KGRTWXLCGTP~
			1JLU	Capk. – SEP & TPO. (Domain is also phosphorylated)	~EEIRVXINEKC~ ~KGRTWXLCGTP~ (~RTGRRAXIHD.)
			1L3R	Capk. – SEP & TPO.	~AAKKGXEQESV~ ~RIGRFXEPHAR~ ~EEIRVXINEKC~ ~KGRTWXLCGTP~
11	API3	1F32.	1F34	Pepsin A.	~TFEATXQELSI~	~TFEATXQELSI~	Ascaris pepsin inhibitor-3 (API3); protein inhibitor that reversibly inhibits aspartic proteinase cathepsin E, and gastric enzymes pepsin and gastricsin. [25].
12	ARM	1G3J, 1IAL.	1I7W	Epithelial-Cadherin.	~VFDYEGXGXEAASL-XSLNSS~	~VFDYEGXGXEAASLXSL-NSS~	ARM has been implicated in mediating protein-protein interactions, but no common features among the target proteins recognized by the ARM repeats have been identified. [26], [27], [28], [29].
13	Cyclin	1VIN.	1E9H	Cdk2.	~PVRTYXHEVVT~	~PVRTYXHEVVT~	Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB). The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). [38], [30], [31], [32], [33], [34], [35].
			1GY3	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H1P	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H1Q	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H1R	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H1S	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H24	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H25	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H26	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H27	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1H28	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1QMZ	Cdk2. P33 protein kinase.	~PVRTYXHEVVT~
			1JSU	Cdk2.	~PVRTYXHEVVT~
14	CDI		1FQ1	Cell Division Protein Kinase 2.	~PVRTYXHEVVT~	~PVRTYXHEVVT~	Cyclin-dependent kinase inhibitor. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase. [36].
15	GlgA	1H8F, 1I09.	1O6L	Serine/Threonine Protein Kinase	~GATMKXFCGTP~	~GATMKXFCGTP~	Glycogen synthase [Carbohydrate transport and metabolism]. [37].
			1O6K	Serine/Threonine Protein Kinase	~GATMKXFCGTP~
16	SH2				???	SH2	SH2 domains typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.
17	StKc				???
18	Psa		1BJN		???		[1].
19	Psp		1F5S		???		[1].

??? – Interesting domains for which structures are not readily available.

* - Consensus from binding sites listed in column 4 and from data in Prosite (if available).